Find for complicated disease " Lost heredity "

Find for complicated disease " Lost heredity "
Complicated disease " Lost heredity " Study and make important progress, researcher succeed in, find coronary heart disease, 2 type diabetes, the intersection of Crohn and to exchange the new location of the sense to order a plurality of complicated disease that traditional analytical method lost such as being ill. Thesis of this research was published on magazine of " science of heredity of public science library " online a few days ago, responsible reader appraises this research for magazine " But the meaningful attempt of success that it is once " .
It is introduced, the related analysis of the whole genome is a, to the common hereditary variation gene overall related analysis method in the whole genome range, in order to understand the morbidity mechanism of the human complicated disease has offered more clues. At present, scientists have already carried on the related analysis of the whole genome to many kinds of complicated diseases such as diabetes, coronary heart disease, lung cancer, prostate cancer, fat, psychosis, and found the relevant exchanging the induction to click of disease. But most such location order lighter to ill contribution of risk, can only explain about 10% of the hereditary function, more than 80% of the heredity is contributed and lost, this phenomenon is known as " lost heredity " in complicated disease research . How to retrieve this kind " Lost heredity " Important subject studied by nowadays science of heredity of complicated disease.
Scientific research personnel such as the auspicious silver doctor, Liu Yang of seminar, of hole of key laboratory of stem cell of the Chinese Academy of Sciences,etc. and southern research center of national human genome, Zhejiang University the intersection of unit and cooperation, break through traditional the intersection of GWAS and limitation that unit analyze a bit under study for action, have set up related analytical method and procedure of the whole genome based on different some interaction of hereditary location, and utilize the public GWAS data, the complicated disease succeeding in finding a plurality of traditional analytical methods and losing, coronary heart disease, 2 type diabetes, the intersection of Crohn and to exchange the new location of the sense, order disease such as being ill.
The expert thinks, this research has not only announced relevance may exist in interaction and ill risk while clicking of different location, and strengthened the human knowledge of some frameworks of hereditary location of complicated disease.
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